UFC Vegas 110 is less than 24 hours away …
It all goes down this weekend (Sat., Nov. 1, 2025) inside the UFC Apex in Las Vegas, Nevada. In the main event, Ultimate Fighting Championship (UFC) Featherweight knockout artists collide as Steve Garcia takes on David Onama.
We have a weekly series here at MMAmania.com called “Weekend Lock,” where we share one bet that we predict will slap in “Sin City” when the chaotic dust settles. We also want to hear what our readers think (that’s you!), so tell us your most confident UFC Vegas 110 betting lock in the comments section below (full UFC Vegas 110 odds here).
Last week’s recap: We are back on track! Mackenzie Dern vs. Virna Jandiroba went the distance in the UFC 321 co-main event, so our lock hit.
Let’s keep on, keeping on below:
UFC Vegas 110 has two Welterweight fights on the main card, but only one of them is going to be an absolute banger for as long as it lasts, as foul-mouthed Charles Radtke takes on Daniel Frunza.
This week, I’m locking in Radtke to win by KO/TKO/DQ or Decision at –130.
Here’s why:
Both Charles Radtke and Daniel Frunza are coming off tough losses and desperately need a win, but Radtke is simply the more complete fighter. The 34-year-old brings real power and crisp combinations to the table, along with solid takedown defense and high-volume pressure. While he’s not perfect defensively, his aggression and willingness to bite down and trade make him a dangerous threat over three rounds.
Frunza, meanwhile, looked out of his depth in his UFC debut, taking a beating from Rhys McKee — who has just one win in the promotion. That kind of damage, combined with Frunza’s defensive lapses and tendency to back straight up when pressured, could spell trouble here.
“Chuck Buffalo” may lose to top fighters in the division like Carlos Prates (watch highlights) or Mike Malott (watch highlights), but he obliterates guys in the bottom of the division — and Frunza is that.
Radtke, who has shown solid cardio and toughness even in defeat, should be able to dictate pace, land the harder shots, and either find a stoppage or win on the scorecards. In other words, this play covers both outcomes for the more proven fighter at a very playable price.
What could go wrong?
Radtke’s style leaves openings — he’s hittable and sometimes too willing to brawl, which could let Frunza find success if he lands something big early. While Frunza took an absolute beating against McKee, he kept coming forward, and although he was hit with a doctor’s stoppage, he was gaining some momentum. If Frunza can survive the early storm and make it ugly, this bet could sweat late.
Still, given the matchup, Radtke by KO/TKO/DQ or Decision (-130) feels like one of the safest ways to back the more polished fighter at UFC Vegas 110.
For what it is worth, this Twitter user is backing Radtke, too.
- Charles Radtke To Win By KO/TKO/DQ: +200
- Charles Radtke To Win By Submission: +500
- Charles Radtke To Win By Decision: +300
- Draw: +5000
- Daniel Frunza To Win By KO/TKO/DQ: +225
- Daniel Frunza To Win By Submission: +2000
- Daniel Frunza To Win By Decision: +700
UFC FIGHT NIGHT RETURNS TO SIN CITY! Ultimate Fighting Championship (UFC) returns to action on Sat., Nov. 1, 2025, with an exciting main event set to headline UFC Vegas 110 from inside UFC APEX in Las Vegas, Nevada. In UFC Vegas 110’s main event, Featherweight contenders Steve Garcia vs. David Onama clash in a high-stakes, five-round bout. UFC Vegas 110’s co-main event features a Heavyweight showdown between Waldo Cortes-Acosta vs. Ante Delija. UFC Vegas 110 will also showcase a women’s Bantamweight clash between Ketlen Vieira vs. Norma Dumont, a Welterweight bout pitting Jeremiah Wells vs. Themba Gorimbo, a Featherweight matchup featuring Isaac Dulgarian vs. Yadier Del Valle, and much more! UFC Vegas 110’s start time is scheduled for 4 p.m. ET (“Prelims” undercard), and 7 p.m. ET (main card).
Remember that MMAmania.com will deliver LIVE round-by-round, blow-by-blow coverage of the entire UFC Vegas 110 fight card, starting with the ESPN+ “Prelims” matches online, which are scheduled to begin at 4 p.m. ET, before the main card start time at 7 p.m. ET (also on ESPN+).
To checkout the latest and greatest UFC Vegas 110: “Garcia vs. Onama” news and notes be sure to hit up our comprehensive event archive right here.
