It’s Tuesday, August 26 and the Padres (74-57) are in Seattle to take on the Mariners (70-61). Dylan Cease is slated to take the mound for San Diego against Luis Castillo for Seattle.
Seattle won the series opener versus San Diego, 9-6, as Cal Raleigh raked in his 50th homer of the season. The Mariners extended their record to 4-0 versus San Diego this year. The Padres have now lost back-to-back games, while Seattle has won consecutive games and three of the past four.
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Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Padres at Mariners
- Date: Tuesday, August 26, 2025
- Time: 9:40PM EST
- Site: T-Mobile Park
- City: Seattle, WA
- Network/Streaming: SDPA, RSNW
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Padres at the Mariners
The latest odds as of Tuesday:
- Moneyline: Padres (-102), Mariners (-118)
- Spread: Mariners 1.5
- Total: 7.0 runs
Probable starting pitchers for Padres at Mariners
- Pitching matchup for August 26, 2025: Dylan Cease vs. Luis Castillo
- Padres: Dylan Cease, (6-11, 4.71 ERA)
Last outing: 7.20 ERA, 4 Earned Runs Allowed, 6 Hits Allowed, 2 Walks, and 7 Strikeouts - Mariners: Luis Castillo, (8-7, 3.57 ERA)
Last outing: 6.75 ERA, 3 Earned Runs Allowed, 10 Hits Allowed, 2 Walks, and 2 Strikeouts
- Padres: Dylan Cease, (6-11, 4.71 ERA)
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Top betting trends & insights to know ahead of Padres at Mariners
- Seattle is 4-0 versus San Diego this season
- The Padres are 0-2 in the last 2 games and 5-2 in the last 7
- Seattle is 4-8 over the last 12 games
- The Padres have won their last 5 road games against teams with worse records
- The Over is 13-10-3 (50%) in the Mariners’ games this season with Luis Castillo as the opener
- The Padres have covered in 4 of their last 5 games showing a profit of 2.97 units
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight’s game between the Padres and the Mariners
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Tuesday’s game between the Padres and the Mariners:
- Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the San Diego Padres at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
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- Jay Croucher (@croucherJD)
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- Vaughn Dalzell (@VmoneySports)
- Trysta Krick (@Trysta_Krick)
