Jack Della Maddalena vs. Islam Makhachev: Odds and what to know for UFC 322 title fight

It’s champion vs. champion in the main event of UFC 322. Lightweight king Islam Makhachev will attempt to capture a title in a second weight class as he moves up to challenge Jack Della Maddalena for the 170-pound title.

Jack Della Maddalena vs. Islam Makhachev preview

Della Maddalena (18-2 MMA, 8-0 UFC) enters his first title defense against a fighter from a lighter weight class. At UFC 315, Della Maddalaena became the 170-pound champion by winning a unanimous decision over Belal Muhammad in a Fight of the Night main event.

Makhachev (27-1 MMA, 16-1 UFC) will move up a weight class in an attempt to capture a second title. Makhachev won the lightweight title at UFC 280 by stopping Charles Oliveira. He then recorded title defenses against Alexander Volkanovski (twice), Dustin Poirier and Renato Moicano.

Jack Della Maddalena vs. Islam Makhachev odds

According to DraftKings, the lightweight champ Makhachev opens as a comfortable favorite at -278. The welterweight champ Della Maddalena sits at +225, which means oddsmakers believe the fighter from the lighter weight class will prevail.

How to watch Jack Della Maddalena vs. Islam Makhachev at UFC 322

Where: Madison Square Garden, New York, N.Y.

Broadcast/streaming: ESPN+ pay-per-view

When: Saturday, Nov. 15, 2025

Verified by MonsterInsights